Monobenzone

Monobenzone exerts a permanent and irreversible depigmenting effect, whose mechanism of action acts on melanocytes, reducing melanin segregation. Available studies show that Monobenzone increases the production of melanin in melanocytes. It increases the degradation of melanosomes, inhibits tyrosinase, and destroys membranous organelles. The mono benzyl ester of hydroquinone is a depigmenting agent that produces permanent depigmentation. It was excluded from its use in conventional depigmenting treatments, reserving only for permanent depigmentation of residual body areas in patients. However, it is a resource that, although valued by the prescribers, has little documentation on results and form of application. From the statistical point of view, 75% of those who use the treatment are women, predominantly dark-skinned people, with an average duration of vitiligo of 15 years and that in more than 80% has a greater affectation of 50% of the body surface. From the galeni